Semaglutide mimics the action of GLP-1, a hormone that increases insulin secretion, inhibits glucagon release, slows gastric emptying, and enhances satiety. The medication promotes weight loss through several mechanisms:
- Appetite Suppression: Semaglutide acts on GLP-1 receptors in the brain, reducing appetite and increasing feelings of fullness, leading to lower food intake.
- Slowed Gastric Emptying: It delays the emptying of stomach contents into the small intestine, prolonging fullness after eating.
- Reduced Caloric Intake: Its effects on appetite and gastric emptying typically result in fewer calories consumed.
- Improved Insulin Sensitivity: Semaglutide enhances insulin sensitivity, contributing to better metabolism and nutrient utilization.